LYMPHOID NEOPLASIA TPL2 kinase regulates the inflammatory milieu of the myeloma niche
نویسندگان
چکیده
Department of Medicine, Division of Hematology/Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI; University of Wisconsin Carbone Cancer Center, Madison, WI; Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece; Department of Oncology, University of Wisconsin-Madison, Madison, WI; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI; and Mayo Clinic-Scottsdale, Scottsdale, AZ
منابع مشابه
TPL2 kinase regulates the inflammatory milieu of the myeloma niche.
Targeted modulation of microenvironmental regulatory pathways may be essential to control myeloma and other genetically/clonally heterogeneous cancers. Here we report that human myeloma-associated monocytes/macrophages (MAM), but not myeloma plasma cells, constitute the predominant source of interleukin-1β (IL-1β), IL-10, and tumor necrosis factor-α at diagnosis, whereas IL-6 originates from st...
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called CS1) and CD38 has been approved by regulatory authorities. Therapeutic approaches using the innate immune system, like natural killer cells and TAA-specific T-cell approaches with chimeric antigen receptors (CARs), are being investigated clinically. Therefore, there is a fervent need for a better understanding of the interaction of the myeloma niche with the immune system to further impr...
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Tumor progression locus-2 (Tpl2) kinase is a major inflammatory mediator in immune cell types recently found to be genetically associated with inflammatory bowel diseases (IBDs). Here we show that Tpl2 may exert a dominant homeostatic rather than inflammatory function in the intestine mediated specifically by subepithelial intestinal myofibroblasts (IMFs). Mice with complete or IMF-specific Tpl...
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OBJECTIVE Activation of extracellular signal-regulated kinase-(ERK)-1/2 by cytokines in adipocytes is involved in the alterations of adipose tissue functions participating in insulin resistance. This study aims at identifying proteins regulating ERK1/2 activity, specifically in response to inflammatory cytokines, to provide new insights into mechanisms leading to abnormal adipose tissue functio...
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OBJECTIVE Obesity-associated low-grade systemic inflammation resulting from increased adipose mass is strongly related to the development of insulin resistance and type 2 diabetes as well as other metabolic complications. Recent studies have demonstrated that the obese metabolic state can be improved by ablating certain inflammatory signaling pathways. Tumor progression locus 2 (TPL2), a kinase...
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